Defective oral tolerance promotes nephritogenesis in experimental IgA nephropathy induced by oral immunization.
L Gesualdo, ME Lamm… - Journal of immunology …, 1990 - journals.aai.org
Oral tolerance, an important feature of the mucosal immune system, appears to protect
against immune-mediated disease by blunting production of systemic IgG and IgM antibody
directed toward immunogens chronically present at mucosal surfaces. In this study, we
explored the role of oral tolerance and mucosal immunoregulation in an experimental model
of IgA nephropathy (IgAN), an important form of nephritis in humans. Cyclophosphamide
and estradiol were used to inhibit the expression of oral tolerance, which otherwise …
against immune-mediated disease by blunting production of systemic IgG and IgM antibody
directed toward immunogens chronically present at mucosal surfaces. In this study, we
explored the role of oral tolerance and mucosal immunoregulation in an experimental model
of IgA nephropathy (IgAN), an important form of nephritis in humans. Cyclophosphamide
and estradiol were used to inhibit the expression of oral tolerance, which otherwise …
